Tag: diphenhydramine

January 5, 2026

Tricyclic Antidepressants and Antihistamines: The Hidden Danger of Anticholinergic Overload

Combining tricyclic antidepressants with first-generation antihistamines like Benadryl can cause dangerous anticholinergic overload, increasing dementia risk and triggering delirium. Learn how to spot the signs and find safer alternatives.