Anastrozole – Key Facts, Benefits, and Risks

When working with anastrozole, a potent aromatase inhibitor used chiefly in hormone‑responsive breast cancer treatment. Also known as Arimidex, it blocks the enzyme that converts androgens into estrogen, effectively lowering estrogen levels in the body.

This drug belongs to the broader class of aromatase inhibitors, medications that suppress estrogen synthesis by inhibiting the aromatase enzyme. By reducing estrogen, anastrozole directly impacts estrogen receptor‑positive breast cancer, a type of cancer that grows in response to estrogen. The therapeutic chain works like this: anastrozole inhibits aromatase → estrogen production drops → cancer cells receive less growth signal → tumor progression slows.

Practical Points You Should Know

Typical dosing for post‑menopausal patients is 1 mg once daily, taken with water and preferably at the same time each day. Because the drug affects bone metabolism, doctors often recommend a baseline bone density test and calcium‑vitamin D supplementation. Common side effects include joint pain, hot flashes, and mild fatigue; serious concerns are osteoporosis and elevated cholesterol, so regular blood work is a must.

Drug interactions matter, too. Anastrozole is metabolized mainly by CYP19, so strong inducers or inhibitors of this pathway can alter its effectiveness. Always flag other hormone‑related medications, such as tamoxifen or letrozole, and inform your pharmacist about supplements like St. John’s wort.

Below you’ll find a curated collection of articles that dive deeper into dosage nuances, safety monitoring, and how anastrozole stacks up against other breast‑cancer therapies. Whether you’re starting treatment, managing side effects, or simply curious about the science, the resources ahead give you solid, actionable insight into anastrozole and its role in modern oncology.